GATTO LAB Sensorimotor Adaptation
Sensory Adaptation
The dorsal spinal cord is organized in spatially restricted modules, each composed of heterogeneous excitatory cell types. The differential recruitment of these modules dictates the generation of sensory modality-appropriate motor reactions, e.g. itch-induced scratching vs touch-driven corrective reflexes (Gatto et al., 2021). These modules rather than being hard-wired are highly flexible, with inhibition playing a major modulatory role. We found that during chronic pain states, disrupted inhibition of the modules that encode touch causes the aberrant recruitment of excitatory neurons, making innocuous mechanical stimuli elicit pain responses (Peirs et al., 2021).
We are continuing to investigate the heterogeneity, function and flexibility of these modular circuits, by:
1. Assessing how sensory information is integrated and broadcasted from the spinal cord to specialized nuclei in the brain
Labeling of all
spinal projections
using an
intersectional
genetic strategy
2. Studying how diabetes- and chemotherapy-induced neuropathies influence the sensory coding in the dorsal horn
3. Addressing how distinct proprioceptive pathways are integrated in the deep dorsal horn